G9a co-suppresses LINE1 elements in spermatogonia
نویسندگان
چکیده
منابع مشابه
piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells.
Transposable elements (TEs) occupy a large fraction of metazoan genomes and pose a constant threat to genomic integrity. This threat is particularly critical in germ cells, as changes in the genome that are induced by TEs will be transmitted to the next generation. Small noncoding piwi-interacting RNAs (piRNAs) recognize and silence a diverse set of TEs in germ cells. In mice, piRNA-guided tran...
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Nearly half of the mammalian genome is occupied by repetitive transposon elements, including longinterspersed nuclear elements (LINEs), short-interspersed nuclear elements, and long terminal repeat retrotransposons. The ability of these transposable elements to propagate and insert randomly throughout the genome plays an important role in genome evolution (1). However, as transposon-mediated in...
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In [11] we showed that the only proper subcontinua of the simple closed curve are arcs and single points. In this article we prove that the only proper subcontinua of the real line are closed intervals. We introduce some auxiliary notions such as ]a,b[Q, ]a,b[IQ – intervals consisting of rational and irrational numbers respectively. We show also some basic topological properties of intervals.
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ژورنال
عنوان ژورنال: Epigenetics & Chromatin
سال: 2014
ISSN: 1756-8935
DOI: 10.1186/1756-8935-7-24